«M.Sc., DEGREE [Choice Based Credit System (CBCS)] Branch IV (A) CHEMISTRY (Specializations in Organic, Inorganic and Physical Chemistry) REGULATIONS ...»
Redox titrations – Redox potentials, theory and feasibility of redox titrations, redox indicators, their choice and application.
Precipitation titrations – Theory and types, Volhard, Mohr and Fejan’s methods.
UNIT IV Analysis of Industrial samples -I Ore and cement analysis – Oxides, sulphides and carbonate ores, one example each. Cement, silicate and glass.
Liquid fuels – Flash point, viscosity, carbon residue aniline point, pour point.
UNIT V Analysis of Industrial samples -II Gaseous fuels – sampling procedure, ultimate and proximate analysis, specific volatile index, ash content, calorific value by bomb colorimeter, and Junker’s calorimeter.
Water analysis – BOD, COD and hardness of water.
1. D.A.Skoog and D.M.West, Fundamentals of Analytical Chemistry, Holt Rinehart and
2. Winston Publications, IV Edn,, 1982.
3. A.I Vogel, Text Book of Quantitative Inorganic Analysis, ELBS III Edn, 1987.
4. A.I Vogel, Text Book of Quantitative Inorganic Analysis, Pearson V Edn 2001.
5. J.G. Dick, Analytical Chemistry, McGraw Hill Publishers, 1974.
6. T.S.Ma and V. Horak, Microscale-Manipulations, John Wiley and Sons, 1976.
1. D.A. Skoog, D.M.West, F.J. Holler and S.R.Crouch, Fundamentals of Analytical Chemistry, VIII Edn., Thomson Brooks/Cole Publishers, 2004.
2. H.A. Stobel Addison, Chemical Instrumentation, Wesley Publishers Co., 1976.
CHE S07 PHARMACEUTICAL CHEMISTRY
UNIT I Introduction Important terminologies - pharmaceuticals, drugs, pharmacodynamics, Pharmacokinetics, pharmacopoea, virus, bacteria, fungus, actinomycetes, metabolites, antimetabolites,LD50 and ED50; Therapeutic index- their use in selecting drugs; assay of drugs; Use of plaster of paris in bone – fracture;
UNIT II Antibiotics, Sulpha drugs and Vitamins Antibiotics-synthesis, assay and structure and uses of penicilline, chloramphenicol and tetracyclines. Sulphonamides- mechanism and action of sulpha drugs, preparation and uses of sulphadiazine, sulphapyridine, sulphathiazole and sulphafurazole;
Vitamins-classification as water soluble and liquid soluble vitamins, sources, deficiencies and assay of vitamins A,B1, B2 and C UNIT III Analgesics and Antiseptics Narcotic analgesics-isolation, pharmacological action and uses of morphine, heroin and codeine; Synthetic analgesics-pethidine and methodone; Antipyretic analgesics-synthesis and structure and action of methyl salicylate, aspirin, paracetamol and phenacetin; Antiseptics and disinfectants-phenol as disinfectant and phenol coefficient; dyes and organo mercurials and cationic surfactants UNIT IV Anaesthetics, Tranquilisers and Antineoplastics Anaesthetics - classification as general, local and intravenous anaesthetics, chemistry of anaesthetic ether, nitrous oxide, halothane, chloroform, thiopental sodium methohexitone, cocaine and benzocaine; Alkaloids - detection of alkaloids, colour reagents; Isolation, colour reaction and SAR of quinine; Tranquilisers, hypnotics and sedatives; Antineoplastic and hypoglycemic agents - detection sugar and serum in urine;
cause and control of diabetes; Oral hypoglycemic agents; causes and control of cancer;
Praparation and uses of thiotepa and cyclophosphoramide.
UNIT V Organic pharmaceutical aids Preservatives and antioxidants, colouring, flavouring and sweetening agents and ointment bases; Blood-blood groups, Rh factor, blood pressure normal, high and low;
control of pressure; Causes and control of anaemia-antianaemic drugs, coagulants and anticoagulants; causes and control of AIDS.
1. T.C. Daniels and E.C. Jorgensen, Text book of organic medicinal and pharmaceutical chemistry, J. B. Lippincott, Philadelphia, 1977.
2. Ashutosh Kar, Medicinal Chemistry, New Age International, 1996.
1. M. Gordon, Psychopharmacological agents, Academic press, New York, 1965.
2. J.M. Ritchie and P.J. Cohen, The pharmacological basis of therapautics, 5th Edn., Macmillan, New York, 1975.
3. D.Lednicer and L.A. Mitscher, Organic Chemistry of drug synthesis, John Wiley &Sons, New York, 1959.
4. J.E. Hoover, Remington’s Pharmaceutical sciences, 15th Edn. Mack Publ.Company, Easton, 1975.
CHE S08 APPLIED CATALYSISHours L T P C UNIT I Reaction Rates Activation energy concepts - arrhenius theory, collision theory – biomolecular and unimolecular reactions, ARR theory, influence of S, H and G on reaction rates with and without catalyst.
UNIT II Homogeneous Catalysis Concepts of acidity – Bronsted – Lewis acids. Concept of base – Brosted – Lewis bases. Acid base strength. Application of acid – base catalysis – alkylation, oxidation and reduction of organic molecules. Advantage and disadvantage of homogeneous catalysts.
UNIT-III Heterogeneous Catalysis Metal and metal oxide catalyst - Metal oxide supported catalyst, polymer supported catalyst. Solid acid and base catalyst – molecular sieves – neutral catalyst – alumino phosphate molecular sieves. Isomorphous substitution. High temperature reactions. Product selectivity concept – pore size, reactant ratio, time on stream, coke deposition and conversion.
UNIT IV Photocatalysts Light absorption, laws of photochemistry, quantum yield, semiconductor concept, photo chemical application of dye degradation, molecular sieves based photo chemical applications.
UNIT V Enzyme Catalysts Reaction specificity, enzyme catalysis mechanism – induced fit, lock and key.
Coenzyme – mechanism. Factors influencing enzyme action – temperature, pH, enzyme concentration and substrate concentration. Michaelis – Menton theory and Lineweaver – Burk plot.
Text Books K.J. Laidler, Chemical Kinetics, IIIrd Edn., Harper and Row publisher, New York, 1.
2. B.Viswanathan, Catalysis: Principles and applications, Narosa Publ., New Delhi, 2004.
3. V. Ramamurthy, Photochemistry in organized and constrained media, VCH Edn., New York, 1991.
(b) Set up and solve the Schrodinger wave equation for a one dimensional simple harmonic oscillator (12) 10.(a) Set up and solve the Schrodinger wave equation for the hydrogen atom (12)
3 (a) Distinguish between (i) The equivalence point and the end point of titration (ii) Primary standard and secondary standard (or) (b) The changes in ionic concentration, which occur during the titration of 100 mL of
0.1 M NaCl with 0.1 M AgNO3. The solubility product of AgCl at the laboratory temperature is 1.2 x10-10. The initial concentration of chloride ions [Cl-] is molL-1, or pCl- = 1. When 50 mL of 0.1 M AgNO3 have been added, 50 mL of 0.1 M AgCl remains in a total volume of 150 mL. At this point calculate the Cl- ion concentration.